Cushing's syndrome hauv dev: cov tsos mob thiab kev kho mob. Cushing's syndrome hauv dev: lawv nyob ntev npaum li cas?

Cov txheej txheem:

Cushing's syndrome hauv dev: cov tsos mob thiab kev kho mob. Cushing's syndrome hauv dev: lawv nyob ntev npaum li cas?
Cushing's syndrome hauv dev: cov tsos mob thiab kev kho mob. Cushing's syndrome hauv dev: lawv nyob ntev npaum li cas?
Anonim

Cov kab mob endocrine yog ib qho ntawm qhov tsis meej tshaj plaws ntawm peb lub cev. Yuav luag tag nrho cov txheej txheem biochemical tshwm sim hauv lub cev yog khi rau cov qog endocrine, thiab qhov hloov me ntsis ntawm qib ntawm cov tshuaj hormones feem ntau ua rau muaj qhov tshwm sim tsis zoo. Yog tias peb tham txog kev kho tsiaj kho tsiaj, feem ntau ua txhaum cai yog Cushing's syndrome. Hauv cov dev, qhov teeb meem no feem ntau tshwm sim thaum muaj hnub nyoog laus, thiab hnub no peb yuav txheeb xyuas kom meej tias nws yog dab tsi thiab koj tuaj yeem daws nws li cas. Kab lus no yog cov ntaub ntawv qhia meej, txawm li cas los xij, txhawm rau kuaj mob thiab xaiv txoj kev kho mob, koj yuav tsum sab laj nrog kws kho mob.

Cushing's syndrome hauv dev
Cushing's syndrome hauv dev

Dab tsi yog Cushing's syndrome hauv dev

Nov yog ib yam kab mob uas tsis tshua muaj tsawg li peb xav. Qhov ua txhaum cai muaj nyob rau hauv qhov tseeb hais tias lub caj pas pituitary ntawm tus tsiaj pib zais cortisol nyob rau hauv ntau heev. Qhov no yog ib qho tseem ceeb heev cov tshuaj hormones, uas yog ib tug haib tshaj ntuj tshuaj rau tiv thaiv kev ntxhov siab. Peb yuav tsis nres ntawmmechanism ntawm qhov cuam tshuam ntawm cov tshuaj no rau lub cev, cia peb hais tias cov tshuaj no txhawb nqa tag nrho cov peev txheej los tiv thaiv qhov tsis zoo ntawm ib puag ncig sab nraud.

Nws zoo nkaus li muaj txiaj ntsig zoo, vim li cas peb, piav qhia txog qhov txheej txheem no, tham txog Cushing's syndrome hauv dev? Qhov tseeb yog tias cov nqi ntawm cov tshuaj hormones uas pib tso rau hauv cov ntshav yog ntau dhau rau tus ntxhw. Thiab lub caj pas pituitary, uas yuav tsum tswj cov tshuaj hormones tsim, feem ntau yog hloov tawm ntawm cov txheej txheem no. Vim li no, koj tus tsiaj tau ntsib qhov tshwm sim tsis zoo.

Cushing Syndrome nyob rau hauv cov tsos mob ntawm tus dev
Cushing Syndrome nyob rau hauv cov tsos mob ntawm tus dev

Txoj Kev Tsis Zoo

Cushing's syndrome hauv dev ua rau muaj kev hloov pauv ntawm tus cwj pwm ntawm tus tsiaj. Kev puas siab puas ntsws yog qhia meej meej. Tus dev yog tormented los ntawm tas li, nkees nqhis dej. Qhov no ua rau muaj qhov hnyav ntawm lub raum, thiab ntxiv rau, ua rau tso zis ntau dhau. Cov kab mob no tuaj yeem ua rau tuag taus, thiab sai heev. Yog vim li cas rau qhov no tau yooj yim piav qhia los ntawm qhov pom ntawm physiology. Lub cev yog nyob rau hauv ib tug mobilized lub xeev, uas txhais tau hais tias nws hnav tawm ob peb zaug sai dua. Hauv kev coj noj coj ua, muaj cov piv txwv thaum lub xeev ntawm lub cev ntawm tus dev muaj peb xyoos nrog tus kab mob no zoo ib yam hauv kev hnav thiab tsim kua muag rau lub cev ntawm tus dev hnub nyoog 13-15.

Cushing's syndrome hauv kev kho dev
Cushing's syndrome hauv kev kho dev

Cov tsos mob tseem ceeb

Tam sim no peb tham txog yuav ua li cas koj yuav xav tias Cushing's syndrome hauv dev. Ua ntej ntawm tag nrho cov, cov tswv tau them sai sai rau qhov nce qab los noj mov. Tus tsiaj pib ntxiv sai heevhauv hnyav. Nyob rau tib lub sijhawm, koj tuaj yeem pom nqhis dej heev thiab tso zis ntau zaus. Tus tsiaj tsis tuaj yeem nyob ntev ntev thiab txawm tias muaj kev taug kev ntau ntxiv, nws tseem pees tom tsev.

Qhov tseeb, tus kab mob no tsis tshwm sim los ntawm qhov twg, tab sis maj mam txhim kho, thiab cov tsos mob hnyav zuj zus. Tus dev yuav qaug zog thiab qaug zog, tsaug zog, tab sis qhia tau hais tias qab los noj mov. Lub plab sags vim tsis muaj zog ntawm lub plab cov leeg. Kev qaug zog sai heev yog pom. Maj mam baldness ntxiv. Ntau thaj chaw ntawm daim tawv nqaij tseem tsis muaj plaub hau. Feem ntau cov no yog thaj chaw ntawm lub cev, tab sis tsis yog ntawm lub taub hau lossis paws. Khaus khaus tsis tuaj. Yog tias tsis kho, ntshav qab zib mellitus tshwm sim sai heev tiv thaiv keeb kwm ntawm tus kab mob no.

Cushing Syndrome nyob rau hauv cov dev yees duab
Cushing Syndrome nyob rau hauv cov dev yees duab

Ua rau kab mob

Qhov tseeb, cov kws kho tsiaj muaj ntau qhov kev xav txog vim li cas dev thiaj raug kev txom nyem los ntawm cov tshuaj hormones no. Txawm li cas los xij, qhov laj thawj tseem ceeb yog hu ua qog uas cuam tshuam rau cov qog adrenal. Feem ntau, cov kws kho mob sim kho tus mob no nrog kev pab ntawm kev phais lossis tshuaj, uas kuj muaj lawv cov kev phiv. Txawm li cas los xij, qhov no tsis yog tib qho laj thawj uas tuaj yeem ua rau Cushing's syndrome hauv dev. Daim duab qhia peb txog kev hloov pauv sab nraud uas tshwm sim nrog cov tsiaj muaj mob, tab sis hauv qab no peb yuav rov qab mus rau cov tsos mob.

Lwm qhov laj thawj tuaj yeem yog pituitary adenoma. Yog li, nws yuav tsum tau kuaj xyuas ob lub qog pituitary thiab cov qog adrenal. Txawm li cas los xij, tau pom cov qog, tus kws kho mob tsuas yog pib nws txoj haujlwm. Nws tseem yuav tsum tau txiav txim siab nrog benignlos yog qhov mob qog noj ntshav uas peb tab tom kho, thiab tsuas yog tom qab ntawd twv seb qhov kev kho mob.

Cushing's syndrome nyob rau hauv dev cov tsos mob kho
Cushing's syndrome nyob rau hauv dev cov tsos mob kho

Kev xav

Muaj qee yam tsiaj uas tus kab mob no muaj ntau dua li lwm tus. Yog li, boxers thiab terriers ntawm txhua yam muaj kev pheej hmoo. Qhov no kuj suav nrog dachshunds, beagles, poodles thiab basset hounds. Feem ntau, tus kab mob no cuam tshuam rau cov neeg laus uas muaj hnub nyoog 7-10 xyoo. Thaum muaj hnub nyoog no, cov kws kho mob tsuas tuaj yeem tswj xyuas qhov mob ntawm lub cev kom ntau li ntau tau. Txawm li cas los xij, Cushing's syndrome kuj tau kuaj pom thaum muaj hnub nyoog me me - hauv cov dev hnub nyoog qis dua ob xyoos. Tus kab mob no txaus ntshai heev vim nws cuam tshuam rau tag nrho cov kabmob thiab cov kab ke ib zaug, thiab yog li ntawd, tsis muaj kev kho kom raug, muaj qhov tshwm sim ntau ntawm cov tsiaj tuag, nrog rau kev txo qis hauv lub neej nrog kev kho kom txaus.

Cushing's syndrome hauv dev lawv nyob ntev npaum li cas
Cushing's syndrome hauv dev lawv nyob ntev npaum li cas

Examination

Nws yog ib qho tseem ceeb heev kom ntseeg tau tias Cushing's syndrome hauv dev. Kev kuaj mob ntawm tus kab mob no yog qhov nyuaj heev, tsis yog txhua lub tsev kho mob tuaj yeem muab cov xwm txheej tsim nyog rau qhov no. Ua ntej tshaj plaws, tus kws kho mob yuav tsum kuaj xyuas tus tsiaj thiab ua qhov kev ntsuam xyuas tsim nyog. Qhov taw qhia yuav yog kev kuaj ntshav thiab biochemical kuaj ntshav, nrog rau kev kuaj zis, uas yog qhov tseem ceeb rau kev kuaj xyuas cov protein.

Yuav kom paub meej cov duab, tus kws kho mob yuav sau x-ray uas yuav pom lub siab loj lossis cov pob zeb hauv cov qog adrenal. Ib qho ultrasound yuav tsum tau txiav txim tawm cov qog.qog adrenal. Kev kuaj mob kom zoo yuav tsum tsis txhob lees paub Cushing's syndrome hauv dev. Cov tsos mob uas yuav tau kho nyob rau hauv cov kauj ruam tom ntej no tej zaum yuav plooj, uas txhais tau tias nws yog ib qho tseem ceeb kom nrhiav tau qhov chaw ntawm qhov teeb meem.

Kev kho mob

Nov yog lub sijhawm nyuaj thiab tseem ceeb heev. Nyob rau theem no, tus kws kho mob yuav tsum xaiv cov kev kho mob uas tsim nyog tshaj plaws. Txhim kho cov qib cortisol, txhawb kev ua haujlwm ntawm txhua lub cev thiab lub cev - qhov no yog lub luag haujlwm tseem ceeb uas nws tau ntsib txij li nws tau kuaj pom tias muaj tus mob Cushing's syndrome. Hauv dev, kev kho mob tuaj yeem ua tau ob txoj hauv kev.

thawj txoj kev yog phais. Nws tsis yog qhia rau txhua tus tsiaj, tab sis tsuas yog rau cov neeg uas muaj qog nqaij hlav ntawm cov qog adrenal. Nyob rau hauv cov ntaub ntawv ntawm ib tug pituitary adenoma, tej yam txawm ntau nyuaj, thiab cov qog adrenal tsuas yog tshem tawm thiab tus tsiaj yog muab tshuaj hormonal mus rau lub neej.

Txoj kev thib ob yog tshuaj. Hauv qhov no, kev kho tshuaj hormone yog siv los normalize cortisol. Qhov no yog Mitotan. Kev txais tos pib nrog ib koob tshuaj 50 mg ib hnub twg rau 1 kg ntawm qhov hnyav. Cov koob tshuaj niaj hnub muab faib ua 2-3 koob tshuaj. Kev kho mob txuas ntxiv rau ob lub lis piam. Tus mob ntawm tus tsiaj yog saib xyuas los ntawm kev kuaj ntshav. Nrog rau qhov txo qis hauv cortisol hauv cov ntshav mus rau qib siab, koj yuav tsum tau hloov mus rau qhov tshuaj noj 50 mg / kg ib zaug ib lub lim tiam.

Qhov kev xaiv thib ob feem ntau tau sau los ntawm kws kho mob yog Ketoconazole. Ua ntej tshaj plaws, nws tau sau tseg rau cov tsiaj uas, tawm tsam keeb kwm ntawm Cushing's syndrome, kuj tsim cov tawv nqaij puas tsuaj. Noj cov tshuaj no hauv thawj lub lim tiam - 10 mg rau 1 kg ntawm qhov hnyav (hauv ob koob). Lub lim tiam thib ob nce qhov koob tshuaj mus rau 20 mg rau 1 kg ntawm qhov hnyav (tseem nyob rau hauv ob koob). Thaum kawg, lub lim tiam thib peb ntawm kev kho mob suav nrog kev noj tshuaj txhua hnub ntawm 30 mg rau 1 kg ntawm lub cev hnyav.

Cushing's Syndrome hauv Dogs Diagnosis
Cushing's Syndrome hauv Dogs Diagnosis

Yuav txiav txim siab li cas ntawm kev kho mob

Ua ntej ntawm tag nrho, kev kuaj ntshav, ultrasound thiab x-ray yuav yog cov ntsiab lus siv. Txawm li cas los xij, muaj cov cim qhia tias tus tswv nws tus kheej tuaj yeem ntsuas tau. Qhov no feem ntau yog txo cov dej haus los ntawm tus dev. Txawm li cas los xij, nws yuav tsum tau nco ntsoov tias tiv thaiv keeb kwm yav dhau los ntawm kev kho tsis tu ncua, tus tsiaj tuaj yeem tsim teeb meem. Qhov no yog ntuav thiab nce qaug zog, lethargy thiab tsis kam noj. Cov tsos mob zoo li no yuav qhia tau tias muaj kab mob sib kis thiab kab mob. Yog li ntawd, rau qhov purity ntawm daim duab, nws yog ib qhov tsim nyog los ua kev soj ntsuam kuaj.

Kev kho mob tau

Koj tuaj yeem cia siab li cas thaum tus dev tau kuaj pom tus mob Cushing's Syndrome? Cov neeg mob no nyob ntev npaum li cas? Cov lus nug no feem ntau nug los ntawm cov tswv rau cov kws kho tsiaj. Nws yuav tsum tau hais tias tus kab mob tau piav qhia tsuas yog qee qhov kho tau. Feem ntau, lub neej expectancy, txawm tias tom qab kev kho mob zoo, tsis pub tshaj 2-3 xyoos. Qhov no yog vim lub fact tias Cushing's syndrome yog ib tug kab mob uas muaj feem xyuam rau tag nrho cov nruab nrog cev thiab systems thiab ua rau ib tug xov tooj ntawm irreversible hloov. Cov no yog cov musculoskeletal, cardiovascular thiab paj hlwb. Nyob rau tib lub sijhawm, tus kab mob no txo qis lub cev tiv thaiv ntau yam kab mob, thiab tseem ua rau muaj ntshav siab ntau ntxiv.

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