"Fraxiparine" thaum cev xeeb tub: tshuaj xyuas, cov lus qhia rau kev siv, contraindications

2024 Tus sau: Priscilla Miln | [email protected]. Kawg hloov kho: 2024-02-18 01:25

Kev tshuaj xyuas tsis sib haum xeeb txog Fraxiparine thaum cev xeeb tub yog qhov tseeb, vim tias cov tshuaj tsis tau dhau qhov kev sim tshuaj xyuas tag nrho. Nws tsis pom zoo siv thaum cev xeeb tub tshwj tsis yog tias cov txiaj ntsig kho tau zoo dua qhov muaj feem pheej hmoo.

Thromboembolism yog ib qho kev phom sij uas ua rau cov hlab ntsha txhaws, cov ntshav tsis txaus nrog kev txhim kho ntxiv ntawm ischemia lossis infarction. Kev siv Fraxiparine thaum cev xeeb tub yog qhov ua tau, vim tias kev ua haujlwm tsis zoo tuaj yeem ua rau muaj kev tsis taus thiab tuag.

Qhov tseem ceeb ntawm cov ntshav ncig kom zoo thaum cev xeeb tub

Txij thawj lub lis piam tom qab xeeb tub, lub cev ntawm tus poj niam cev xeeb tub nce qhov ntim ntawm cov ntshav. Qhov siab tshaj plaws tau pom nyob rau ntawm 31-34 lub lis piam. Nyob rau hauv lub xeev ib txwm, cov kua ib feem ntawm cov ntshav nce, vim nws cov viscosity ntau dhau lawm, tsis muaj kev pheej hmoo ntawm cov ntshav txhaws.

Muaj ib feem puacov poj niam uas muaj ntshav txhaws. Cov kev sib txawv no tuaj yeem tshwm sim los ntawm qhov tsis txaus ntawm cov tshuaj hormones, txo qis kev ua haujlwm, lossis los ntawm cov kab mob sib kis. Nws yog tsim nyog sau cia tias cov txheej txheem physiological hauv lub cev nws tus kheej tuaj yeem ua rau hypercoagulability.

Clogs tsim teeb meem rau kev xa cov pa oxygen thiab kev hloov pauv ntawm cov kab mob mus rau qhov chaw mob ntev yog qhov txaus ntshai rau kev loj hlob ntawm tus menyuam hauv plab thiab tuaj yeem cuam tshuam rau lub paj hlwb, cov hlab ntsha thiab kev ua haujlwm myocardial.

Kev phom sij yog qhov txhaws ntawm cov hlab ntsha hauv lub ntsws feem ntau xaus rau kev tuag.

Txij li thawj lub lim tiam ntawm cev xeeb tub, tus poj niam yuav tsum tau sau npe nrog tus kws tshaj lij. Tau txheeb xyuas thawj cov cim qhia ntawm kev hem thawj, cov txheej txheem tiv thaiv kev tswj tau raug sau tseg. Kev noj zaub mov noj, kev ua kis las thiab, yog tias tsim nyog, cov tshuaj tiv thaiv coagulant pab tau zoo.

Leej twg qhia qhov kev taw qhia ntawm "Fraxiparine"

Raws li cov lus qhia, "Fraxiparine" thaum cev xeeb tub yog siv los ua kev tiv thaiv kev tiv thaiv kom tsis txhob muaj ntshav khov ntau dhau, uas tom qab ntawd ua rau muaj kev loj hlob ntawm thrombosis. Cov tshuaj kuj tau qhia rau kev siv kho mob:

• thromboembolism;
• tsis pom kev placental blood flow;
• cim qhia ntawm fetal hypoxia;
• angina;
• mob plawv (tsis muaj Q).

Nws yog ib qho tshuaj uas nquag sau tseg uas tiv thaiv cov teeb meem thaum muaj kev phais, kev kho mob orthopedic. Tiv thaiv cov ntshav txhaws thaum lub sij hawm hemodialysis.

Cov poj niam cev xeeb tub tau muab tshuaj nrog kev ceev faj tshwj xeeb thaum muaj kev pheej hmoo ntawm kev mob qog noj ntshav thiab muaj kev phiv tshwm sim ntawm cov nplai. Nrog ntshav txhaws, thaum lub cev tsis tsim cov tshuaj tiv thaiv coagulants, cuam tshuam nrog kev tshuaj xyuas tsis zoo, Fraxiparine yuav tsum tau noj thaum cev xeeb tub. Yog li, qhov kev hem thawj ntawm intrauterine fetal fading tsis suav nrog. Cov ntshav tuab cuam tshuam nrog kev kho kom zoo ntawm lub embryo rau phab ntsa uterine, tsim cov placenta.

Yuav ntev npaum li cas ntawm cov tshuaj

Cov kws kho mob tsis muaj lub hom phiaj ua mob rau tus neeg mob. Gynecologists ntseeg tau tias Fraxiparin tsis ua mob rau leej niam thiab tus menyuam hauv plab, tab sis tsis yog thaum ntxov. Kev teem caij ntawm cov tshuaj tsis suav nrog hauv thawj peb lub hlis twg, vim nws tuaj yeem ua rau nchuav menyuam. Hauv peb lub hlis thib ob, cov tshuaj tau sau tseg los ntawm tus kws tshaj lij hauv kev saib xyuas, yog tias qhov ntsuas tau qhia tias muaj ntshav txhaws.

Kev sib xyaw ntawm Fraxiparine hauv kev txhaj tshuaj

Cov tshuaj nquag ntawm Fraxiparine yog calcium nadroparin. Cov khoom siv pabcuam yog calcium hydroxide lossis dilute hydrochloric acid.

Cov khoom tau txais txiaj ntsig nrog cov tshuaj tiv thaiv kab mob muaj zog thiab kev ua haujlwm kub ntxhov mus ntev.

Kev taw qhia ntawm cov tshuaj ua rau kom nqus tau cov tshuaj nquag los ntawm 88%. Qhov siab tshaj plaws plasma saturation tau kaw tom qab 3-4 teev. Nws muaj peev xwm yuav metabolized hauv daim siab, tawm ntawm lub cev ib hnub. Lub active nyhuv ntawm cov tshuajkav ntev txog 18 teev.

Nws yuav tsum tau muab sau tseg tias cov tshuaj tsis raug sau tseg rau cov poj niam cev xeeb tub uas muaj lub raum tsis ua haujlwm, raws li qhov no nws khaws cia hauv lub raum. Yog tias tus kws kho mob txiav txim siab mus kho mob ntxiv, qhov koob tshuaj yuav tsum raug txo.

Ib daim foos

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm kev txhaj tshuaj. Ntim hauv cov koob txhaj tshuaj pov tseg nrog ntau npaum li 0.3/2850 IU; 0.4/3800 IU; 0.6/5700 IU; 0.8/7600 IU ml. Qhov ntim ntawm Fraxiparine txhaj rau hauv plab thaum cev xeeb tub yog txiav txim los ntawm tus kws tshaj lij. Tus nqi ntawm cov khoom yog cuam tshuam los ntawm qhov hnyav ntawm tus neeg mob, muaj contraindications, concomitant pathologies, tus kab mob ntawm tus poj niam. Lub sijhawm ntawm kev kho mob kuj suav nrog tus kws kho mob. Qee zaum kev txhaj tshuaj tau qhia thoob plaws lub sijhawm cev xeeb tub, tab sis peb tuaj yeem xaus lus los ntawm ntau qhov kev tshuaj xyuas tias Fraxiparine raug tshem tawm ntawm 36-37 lub lis piam ntawm cev xeeb tub. Kev saib xyuas ntxiv ntawm tus niam uas xav tau nyob hauv tsev kho mob.

Dab tsi yog tshuaj

Kev ua haujlwm tsis zoo ntawm cov hlab ntsha, ua txhaum ntawm kev ncaj ncees ntawm cov tsiaj ntshav sov, ua rau kev ua kom muaj kev cuam tshuam ntawm kev ua haujlwm. Thrombocin pib ua kom nquag plias, ua rau cov ntshav khov. Vim yog gluing ntawm cov hlwb, ib qho txhaws tau tsim uas thaiv cov ducts. Kev tsim tawm tsis tu ncua ntawm thrombocin tsim thrombocytosis - tsim cov ntshav txhaws hauv cov hlab ntsha tsis zoo.

Txhaj tshuaj - anticoagulant. Nws qhov kev txiav txim yog tsom rau kev txwv cov txheej txheem ntawm thrombosis. Cov khoom xyaw tseem ceeb yog fraxeparin-nadroparin calcium. Tom qab kev taw qhiaCov tshuaj no cuam tshuam nrog cov protein, ua rau cov ntshav plasma thinning.

Kev ua txhaum ntawm cov ntshav ua rau tsis muaj zaub mov zoo thiab cov pa oxygen rau hauv nruab nrog cev thiab cov ntaub so ntswg, tus menyuam hauv plab kuj raug kev txom nyem los ntawm hypoxia. Tom qab ntawd, xws li kev loj hlob ntawm cov xwm txheej yog fraught nrog spontaneous rho menyuam.

Yuav ua li cas thiaj txhaj tshuaj zoo

Muaj lwm hom kev tso tawm - ntsiav tshuaj, tab sis lawv tsis raug tshuaj rau cov poj niam cev xeeb tub txhawm rau tshem tawm cov txiaj ntsig ntawm lub plab zom mov thiab lub siab ua haujlwm. Cov tshuaj no tsis muaj menyuam thiab tuaj yeem muab tshuaj subcutaneously lossis intravenously. Thaum lub sij hawm cev xeeb tub, cov kws kho mob siv cov txheej txheem subcutaneous thiab tshuaj xyuas ntawm Fraxiparine thaum cev xeeb tub tsis zoo, vim tias cov txheej txheem mob. Qee lub sij hawm nws yog qhov tseeb tias kev txhaj tshuaj yog tsim nyob rau hauv lub plab uas ua rau cov neeg mob ntshai tshaj plaws, bruises thiab pob. Kev kho mob ntev ntev, feem ntau cov poj niam txuas ntxiv kho hauv tsev, yog li koj yuav tsum paub yuav ua li cas txhaj Fraxiparine thaum cev xeeb tub.

Algorithm of actions:

• lub koob txhaj tshuaj tau muab nrog rab koob nce, cua tawm mus txog thaum lub tee tshwm ntawm qhov kawg ntawm rab koob;
• qhov chaw txhaj tshuaj yog kho nrog paj rwb swab dipped hauv cawv (midline ntawm lub plab, 2 ntiv tes hauv qab ntawm lub plab);
• khaw daim tawv nqaij quav nrog ntiv tes ntsug;
• ib rab koob tau muab tso rau hauv sab saud ntawm lub quav, qhov perpendicular rau ntawm daim tawv nqaij;
• txoj kev daws yog tswj kom du, maj mam;
• tom qab rab koob tshem tawm, paj rwb ntub dej cawv yog siv rau qhov chaw sib tsoo.

Tsis txhob rub thaj chaw ntawm daim tawv nqaij tom qab txhaj tshuaj. Tsis tas li ntawd tsis txhob ua haujlwm.peb lub hlis twg ntawm ib teev. Cov koob tshuaj pom zoo rau kev tswj hwm ntawm Fraxiparine thaum cev xeeb tub yog 0.3 mg.

Txoj kev ntawm kev txhaj tshuaj thaum cev xeeb tub

Poj niam lub cev hloov pauv thaum cev xeeb tub. Nrog rau qhov ntim, cov hlab ntsha thiab capillaries nce. Ntshav stasis ua rau kev txhim kho ntawm cov txheej txheem pathological thiab ua tsis taus pa ntev ntawm tus menyuam hauv plab. Nws tseem yog ib qho tseem ceeb kom nkag siab tias nyob rau hauv cov theem tom ntej, compression ntawm cov leeg ntawm lub plab me me los ntawm lub tsev menyuam yog qhov tsis tuaj yeem, uas ua rau muaj kev ua txhaum ntawm cov ntshav tawm ntawm cov leeg ntawm ob txhais ceg. Raws li kev txheeb xyuas pom tseeb, "Fraksiparin" thaum cev xeeb tub yog ib qho tshuaj zoo los tiv thaiv kev tsim cov ntshav txhaws. Nws yog ib qho tseem ceeb uas yuav tsum tsis txhob suav nrog thrombosis ntawm qis extremities thiaj li tsis mus provoke txoj kev loj hlob ntawm pulmonary embolism. Yog tias koj delve rau hauv cov lus qhia, Fraxiparine thaum cev xeeb tub tsis ua rau muaj kev phom sij, tab sis nws siv tsuas yog thaum xav tau ceev.

Puas txhaj tshuaj txaus ntshai thaum cev xeeb tub

Hnub no, "Fraxiparine", raws li kws kho mob, suav hais tias yog ib qho txiaj ntsig zoo ntawm kev tiv thaiv thiab kho thrombosis. Qhov tseeb tias cov tshuaj txhaj rau hauv lub plab yog qhov txaus ntshai rau qee tus, tab sis koj yuav tsum tsis txhob ntshai. Nws yog ib qho tsim nyog los tso siab rau qhov kev ua ntawm tus kws tshaj lij. Cov tshuaj yog txhaj rau hauv cheeb tsam umbilical, tab sis qhov no tsis ua mob rau tus menyuam hauv plab thiab tsis cuam tshuam rau lub sijhawm cev xeeb tub. Kev ua kom ntshav khov ntau dua yog qhov txaus ntshai, yog li ntawd, nws tsim nyog muab qhov kev xav tsis thoob thiab coj lub zog los kho cov hlab ntshav - qhov no yog qhov koj saib xyuas koj niam thiab menyuam.

Cov kws kho mob uas muaj kev paub dhau los tsis lees paub qhov tsis zoo thiab kev tshuaj xyuas tsis zoo txog Fraxiparine thaumcev xeeb tub, raws li cov tshuaj tshem tawm qhov kev hem thawj ntawm kev rho menyuam tawm thiab kho cov ntshav txhaws, tsis hais qhov nyuaj ntawm rooj plaub.

Contraindications thaum cev xeeb tub

Ua ntej yuav muab tshuaj kho mob, tus kws kho mob yuav tsum ntsuas qhov xwm txheej kom raug. Yog tias qhov txiaj ntsig rau leej niam ntau dua li qhov xav tau ua rau tus menyuam hauv plab, tsuas yog txwv tsis pub muaj kev txwv.

Thaum cev xeeb tub, qhov laj thawj tsis kam kho tej zaum yuav yog:

• kev tiv thaiv tus kheej rau cov tshuaj nquag;
• tsis txaus ntawm cov ntshav txhaws, los ntshav (coagulopathy);
• thrombocytopenia;
• organic puas;
• taub hau, nraub qaum, qhov muag raug mob;
• tsis muaj txiaj ntsig ntawm cov tshuaj tiv thaiv kab mob.

Kev kho mob yog ua los ntawm kev saib xyuas ntawm tus kws tshaj lij. Ua tib zoo saib xyuas qhov ua tau tshwm sim ntawm cov kev mob tshwm sim hauv daim ntawv ntawm pob khaus, khaus, urticaria. Qhov tshwm sim hnyav dua uas yuav tsum tau muaj kev cuam tshuam thaum muaj xwm txheej ceev yog Quincke's edema, anaphylactic shock. Kev ntim ntau dhau tuaj yeem ua rau los ntshav. Txawm tias qhov tsawg kawg nkaus npaum li cas, txiav txim los ntawm kev tshuaj xyuas - 0.3 Fraxiparine thaum cev xeeb tub yuav tsum tau saib xyuas ntawm cov kws tshaj lij.

Cov neeg mob lub raum tsis ua haujlwm, nrog rau lub raum tsis ua haujlwm hnyav, tsis txhob siv cov tshuaj no. Tus kws kho mob xaiv cov tshuaj analogues tsis zoo rau kev ua haujlwm ntawm lub cev. Nyob rau hauv daim ntawv me me mus rau nruab nrab, chav kawm tuaj yeem saib xyuas los ntawm tus kws tshaj lij, tab sis nrog kev txo qis, txhawm rau tiv thaiv kev txhim kho.thromboembolism.

Siv tshuaj nrog ceev faj

Fraxiparine tuaj yeem raug sau rau ntawm qhov txaus ntshai los ntshav, nyob rau hauv kev saib xyuas kev kho mob yog tias:

• siab tsis ua hauj lwm;
• raum tsis ua haujlwm;
• mob ntshav siab;
• peptic ulcers;
• tsis ua tiav hauv cov ntshav ncig hauv lub plhaub thiab retina ntawm lub qhov muag;
• xav tau kev kho mob ntau dua kaum xyoo;
• kev sib xyaw nrog cov tshuaj uas ua rau muaj qhov tshwm sim los ntshav.

Leej twg txaus ntshai

Tus kws kho mob gynecologist tshuaj xyuas tus neeg mob cov keeb kwm kho mob kom meej. Yog tias tus poj niam cev xeeb tub yav dhau los tsis muaj kev xeeb tub, tsis muaj peev xwm tiv taus tus menyuam hauv plab, kab mob phlebological, kev kho mob nrog Fraxiparine feem ntau yuav raug tshuaj.

Cov lus qhia tshwj xeeb

Ua ntej yuav siv cov tshuaj uas muaj nyob rau hauv cov chav kawm ntawm qhov hnyav molecular heparins, koj yuav tsum ua tib zoo kawm cov lus qhia. Them tshwj xeeb rau cov koob tshuaj.

Kuj tseem ceeb los xav txog:

• hloov pauv ntawm cov tshuaj uas tsis muaj molecular hnyav heparin yog qhov tsis lees txais;
• tshuaj ntawm tib lub npe nrog cov npe "Forte" yuav tsum tau kho dua ntawm cov tshuaj;
• kev ntsuas ntawm cov koob txhaj tshuaj yog tsim nyog los xaiv cov koob tshuaj raws li qhov hnyav;
• tshuaj tsis yog tshuaj intramuscularly;
• nyob rau hauv cov chav kawm ntawm kev kho mob, kev soj ntsuam xyuas ntawm kev hloov pauv hauv platelet concentration yog ua tiav.

Nyob rau hauv tsawg zaus, nrog cov hlab ntshalos yog venous thrombosis, thrombocytopenia tshwm sim, uas yuav tsum tau txiav txim siab thaum:

• thrombocytopenia;
• qis platelets;
• nrog kev tsis zoo ntawm kev kuaj mob thrombosis;
• DIC.

Cov xwm txheej saum toj no yog vim li cas cuam tshuam kev kho mob.

Yog cov lus nug tshwm sim txog lub peev xwm tsav tsheb, ces tsis muaj ntaub ntawv qhia txog qhov cuam tshuam ntawm Fraxiparine ntawm lub peev xwm ntawm tus poj niam cev xeeb tub los tiv thaiv cov txheej txheem.

Thaum yuav cov tshuaj, xyuam xim rau hnub tas sij hawm, kev ncaj ncees ntawm pob. Txhawm rau kom tsis txhob muaj kev dag ntxias lossis ua kev sib tham nrog cov neeg muag khoom tsis ncaj ncees, nws raug nquahu kom yuav cov tshuaj txhaj tshuaj hauv cov khw muag tshuaj lossis cov khw muag khoom online uas ntseeg siab.

Qhov ntsuas kub ntawm cov tshuaj yuav tsum tsis txhob khov cov tshuaj. Tsis tas li ntawd, tus pas ntsuas kub tsis tuaj yeem nce siab tshaj +30. Ib cov tshuaj los ntawm daim ntawv B yog muab khaws cia rau hauv qhov chaw uas menyuam yaus nkag tsis tau.

Drug compatibility

Txhawm rau tiv thaiv kev txhim kho ntawm hyperkalemia, Fraxiparine tsis siv ib txhij nrog cov tshuaj potassium-sparing diuretics, potassium ntsev, ACE inhibitors, Cyclosporine, Tacrolimus.

Nws yuav tsum raug coj mus rau hauv tus account tias tsis yog-steroidal PVP thiab Aspirin, indirect anticoagulants txhim kho ib leeg qhov kev ua.

Kev siv cov tshuaj tiv thaiv kab mob sib xyaw ua ke tuaj yeem ua rau los ntshav.

Analogues

Yog tias vim li cas nws tsis tuaj yeem yuav Fraxiparine, nws cov qauv analogue ntawm cov tshuaj nquag yogFraxiparine Forte

Yog tias tus neeg mob tau kuaj pom tus neeg tsis kam rau cov tshuaj lossis muaj lwm yam tsis txaus ntseeg rau Fraxiparine, tus kws kho mob tuaj yeem sau tshuaj los ntawm tib pab pawg kws tshuaj nrog cov khoom sib txawv hauv cov qauv:

• Agioks, Angioflux, Anfibra, Arixtra.
• Warfarex, Viathromb, Warfarin.
• Calciparin, Clexane, Xarelto.
• Lavenum, Lyoton, Marevan.
• "Pelentan", "Piyavit", "Pradaksa".
• YSeprotin, Sinkumar.
• "Trombofob", "Trombless", "Troparin"
• Cibor, Fragmin, Fenilin.
• Eliquis, Emeran, Exanta.

Ib qho piv txwv raug xaiv los ntawm tus kws kho mob tuaj koom, suav nrog txhua yam ntawm cov xwm txheej tshwj xeeb.

Zaj lus

Txawm hais tias nws raug pom zoo los sau cov tshuaj qis molecular hnyav heparins thaum lub sijhawm cev xeeb tub - cov lus nug tseem qhib. Nws yuav tsum raug coj mus rau hauv tus account tias cov lus qhia tau kos rau ntau xyoo dhau los, thiab cov kev ntsuam xyuas muaj peev xwm ua kom muaj kev nyab xeeb tsis tau ua tiav. Txawm li cas los xij, muaj cov poj niam uas xav tau kev kho mob anticoagulant txaus ntshai. Koj yuav tsum tsis txhob tsom rau kev tshuaj xyuas ntawm kev siv Fraxiparine thaum cev xeeb tub. Tsuas yog tus kws kho mob, suav nrog tag nrho cov nuances (tus neeg mob tus mob, comorbidities, lub sijhawm) tuaj yeem txiav txim siab qhov xav tau ntawm kev siv tshuaj Fraxiparine.